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1, vacuum drying oven
The vacuum drying oven is an older drying device. The heated plates in the oven are divided into several layers. The hot plate or the low-pressure steam is used as a heating medium in the heating plate. The tray plated with the medicine to be dried is placed on the heating plate, the door is closed, and the inside of the box is vacuumed by a vacuum pump. The heating plate heats the medicine to a specified temperature in the circulating flow of the heating medium, and the water starts to evaporate and gradually withdraws with vacuum. This equipment is easy to control, can condense and recover the evaporated solvent, and the drug can not be contaminated during the drying process. It can be used for drying medicines, sterilization of packaging materials and heat treatment. In the 1980s, the raw material medicine industry used this equipment as the main dryer. However, due to the difficulty in on-line cleaning and on-line sterilization of the tray, the drying speed was slow, and the labor intensity of the workers was large. In order to achieve the homogeneity of the medicine, after drying, Mixing by powder mixing device, the raw material drug has been rarely used in large-scale production, and is mostly used for medium and small pilot production or heat treatment of packaging materials.
2, vacuum rotary dryer
Vacuum rotary dryers are derived from double cone mixers, mostly cylindrical bodies, two cones, also known as double cone dryers. There are two hollow suspension shafts in the middle of the cone, which are used to support the rotation of the equipment and the passage of vacuum and hot water. The medicines rotate while drying in the desiccator, which ensures good uniformity of the whole batch of medicine. The heat medium enters the jacket from a hollow tube at one end, and the hot gas in the apparatus is exhausted with the exhaust pipe in the hollow tube at the other end, and the volatilized solvent is recovered through condensation. This equipment was developed by the Shanghai Pharmaceutical Industry Research Institute in the 1980s and successfully tested on the penicillin production of our company. It was quickly promoted in the national antibiotic industry. There are many domestic manufacturers. Later, the uniaxial rotary dryer multi-dimensional rotary dryer, inclined rotary dryer and similar products appeared. This equipment is equipped with a vacuum system, solvent recovery system, cleaning and sterilization systems. Because this equipment is easy to operate, batch production is easy to adjust, online cleaning and on-line sterilization are possible. Therefore, it has become the preferred desiccator for small and medium-sized antibiotics drug companies, and penicillin, lincomycin, chlortetracycline, and caffeine can all be used. When selecting the equipment, the concentricity of the two hollow shafts and the sealing of the hollow shaft are mainly considered. In order to ensure a stable operation of the equipment, the concentricity requires the axial runout to be less than 0.01 mm. The sealing effect of the hollow shaft is mainly to prevent the lubricant or filler from contaminating the medicine. .
3, three-in-one equipment
Three-in-one means that the three processes of filtration, washing, and drying are combined in the same equipment and are very representative in the pharmaceutical industry. Such equipment has developed rapidly since the 1990s and is divided into belt type and tank type. Centrifugal and other types.
Belt type three-in-one has two kinds of step type and continuous type, mainly because the filter belt has different advancement methods. The same work flow is uniformly placed on the filter belt by the feeder, and the filter belt is dragged by the transmission device in the dryer. Move inside. In the washing and filtering section, the solvent is washed, and the solvent mother liquor is vacuum-cooled to recover the solvent; the hot air in the drying section enters, and the vacuum is removed and condensed to recover the solvent. For mass production batch production, suitable for drying of particles with good air permeability, and the finished product is evenly dried. It is widely used in the vitamin C and penicillin industries in China. Due to the relatively poor tightness of this equipment, online cleaning and online sterilization cannot be well arranged, so it is only suitable for the drying of non-sterile APIs and pharmaceutical intermediates. This device feeder and filter belt correction device play a key role in the normal operation of the equipment. In addition, supporting facilities such as heaters and vacuum systems also have a great influence on the equipment yield. Such equipment used in the pharmaceutical industry is mainly imported or self-assembled with imported major components. Domestically produced equipment of this type is used only in chemical and food medicine and other industries. In recent years, companies in the pharmaceutical industry also have imitations, but have succeeded in the pharmaceutical industry. Applications are rare. Three-in-one can, the tank is similar to a large suction filter, the chassis is a combination of metal sintered plate filter, support plate and heating plate, the can body has a jacket for heating and cooling, the tank has a stirrer that can move up and down The stirrer is a hollow structure that is passed through a medium for heating and cooling and plays a major role in the drying stage. After the material enters the equipment, it shall be filtered by suction, then added to the washing medium for a certain period of time, cold or pressure filtered to a certain extent, the stirring, the chassis, and the jacket shall be passed into the heating medium at the same time, and vacuum shall be used for drying. According to experience and sampling Stop drying after passing and discharge from the discharge port. Stirring and sintering plates for this equipment are the most critical, and supporting equipment includes hydraulic systems, vacuum systems, heating and cooling units. Because this equipment is completely enclosed, if additional automatic discharge system is provided, the equipment can be fully cleaned online (CIP) and online sterilized (SIP), so it is very suitable for the production of sterile bulk drugs, in recent years, such Equipment has been widely used in the production of penicillin sodium salt and hemizygous antibiotics. In the 21st century, with the accelerating pace of GMP certification, China's pharmaceutical machinery industry has vigorously developed or copied similar imported equipment. However, because of the gap in processing accuracy and process control, domestically produced triple-in-one equipment is mainly used in the production of non-sterile APIs. on.
Centrifugal three-in-one, on the basis of the vertical filter centrifuge to increase the function of hot air drying, filter bags or metal filter plate and other forms, the production process and the tank three-in-one is basically the same, but the pumping Changing to centrifugal drying can greatly reduce the production time of a single batch of materials, but due to the limitation of the volume of the centrifuge bin, the single batch production capacity is limited, and it is more suitable for the production and use of sterile bulk pharmaceuticals in medium and small batches. Because this equipment can put the bin and transmission device separately in the sterile room and outside, equipment maintenance does not need to enter the sterile room, and the production and use are very convenient. In recent years, there have been joint ventures in the domestic raw material medicine industry to introduce such equipment. Domestically, imitation products have also been introduced in recent years.
China's raw material medicines and pharmaceutical intermediates (hereinafter referred to as APIs) occupy an important position in the international market at a low price. China's accession to the WTO not only brings opportunities for the pharmaceutical industry, but also brings new challenges to the pharmaceutical industry. For various purposes, the importing countries of raw material drugs have made higher demands on the production process and social responsibilities of pharmaceutical companies in China in the past two years. Therefore, various certifications are rapidly launched in the pharmaceutical industry, and at the same time, the quality of pharmaceutical production in China. Management Practices (GMP) certification is also accelerating the process. The focus of these certifications is on concentrates, stems, and packages for APIs, and the proper selection of dryers is particularly important. The drying device must comply with GMP requirements to ensure that the drug production process is reasonable, the product is uniform, there is no material accumulation, and the cleaning inplace (CIP) requirements can be met. The drying device for the sterile bulk drug must also meet the on-line sterilization ( SterilizinginPlace, SIP) requirements. At present, there are many kinds of raw material drug dryers in China, roughly including vacuum drying ovens, vacuum rotary dryers, three-in-one, air dryers, spray dryers, fluidized beds, fluidized beds, and freeze dryers. The following is a brief discussion of their respective characteristics and applicable conditions.